Novel organelle-targeting signals in viral proteins
نویسندگان
چکیده
منابع مشابه
Novel organelle-targeting signals in viral proteins
INTRODUCTION Peroxisomes are vital cellular organelles controlling important metabolic functions like hydrogen peroxide degradation, fatty acid metabolism, gluconeogenesis, toxin degradation, etc. (Flatmark et al., 1988; van den Bosch et al., 1992; Masters, 1997; Lopez-Huertas et al., 2000). Certain human metabolic disorders such as Zellweger syndrome, neonatal adrenoleukodystrophy, infantile R...
متن کاملTargeting signals in peroxisomal membrane proteins.
Peroxisomal membrane proteins (PMPs) are encoded by the nuclear genome and translated on cytoplasmic ribosomes. Newly synthesized PMPs can be targeted directly from the cytoplasm to peroxisomes or travel to peroxisomes via the endoplasmic reticulum (ER). The mechanisms responsible for the targeting of these proteins to the peroxisomal membrane are still rather poorly understood. However, it is ...
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Drug discovery and drug delivery are two main aspects for treatment of a variety of disorders. However, the real bottleneck associated with systemic drug administration is the lack of target-specific affinity toward a pathological site, resulting in systemic toxicity and innumerable other side effects as well as higher dosage requirement for efficacy. An attractive strategy to increase the ther...
متن کاملMultiple Distinct Targeting Signals in Integral Peroxisomal Membrane Proteins
Peroxisomal proteins are synthesized on free polysomes and then transported from the cytoplasm to peroxisomes. This process is mediated by two short well-defined targeting signals in peroxisomal matrix proteins, but a well-defined targeting signal has not yet been described for peroxisomal membrane proteins (PMPs). One assumption in virtually all prior studies of PMP targeting is that a given p...
متن کاملThe prediction of organelle-targeting peptides in eukaryotic proteins with Grammatical-Restrained Hidden Conditional Random Fields
MOTIVATION Targeting peptides are the most important signal controlling the import of nuclear encoded proteins into mitochondria and plastids. In the lack of experimental information, their prediction is an essential step when proteomes are annotated for inferring both the localization and the sequence of mature proteins. RESULTS We developed TPpred a new predictor of organelle-targeting pept...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2003
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/19.1.10